英格恩RNA体内转染产品相关文献清单

序号

研究方向

实验材料

文章题目

期刊

大脑

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1

大脑皮层

miRNA mimic and inhibitor

Significant changes in circular RNA in the mouse cerebral cortex around an injury site after traumatic brain injury

Experimental Neurology

2

大脑（阿尔兹

海默症）

miRNA

MicroRNA-23b attenuates tau pathology and inhibits oxidative stress by targeting GnT-III in Alzheimer’s disease

Neuropharmacology

3

大脑海马

shRNA

Chemokine CXCL13 acts via CXCR5-ERK signaling in hippocampus to induce perioperative neurocognitive disorders in surgically treated mice

Journal of Neuroinflammation

4

大脑海马

siRNA

Silencing of PTEN inhibits the oxidative stress damage and hippocampal cell apoptosis induced by Sevoflurane through activating MEK1/ERK signaling pathway in infant rats

Cell Cycle

5

血脑屏障

siRNA

Semaphorin 3A Contributes to Secondary Blood–Brain Barrier Damage After Traumatic Brain Injury

Frontiers in Cellular Neuroscience

6

脑缺血损伤

agomiRNA

miR‑183‑5p attenuates cerebral ischemia injury by negatively regulating PTEN

Molecular Medicine REPORTS

7

脑缺血损伤

miRNA agomir

Inhibition of miR-200b-3p alleviates hypoxia-ischemic brain damage via targeting Slit2 in neonatal rats

Biochemical and Biophysical Research Communications

8

脑损伤

miRNA inhibitor

The role of microRNA-146a in regulating the expression of

IRAK1 in cerebral ischemia-reperfusion injury

Canadian Journal of Physiology and Pharmacology

9

脑水肿

dsRNA

Effect of AQP4-RNAi in treating traumatic brain edema: Multi-modal MRI and histopathological changes of early stage edema in a rat model

EXPERIMENTAL AND THERAPEUTIC MEDICINE

10

大脑神经

siRNA

Long non-coding RNA MEG3 functions as a competing endogenous RNA to regulate is chemic neuronal death by targeting miR-21/PDCD4 signaling pathway

Cell Death and Disease

11

大脑神经

miRNA

miR-21 regulates ischemic neuronal injury via the p53/Bcl-2/Bax signaling pathway

AGING

神经

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1

背根神经

shRNA

Dihydromyricetin Alleviates Diabetic Neuropathic Pain and Depression Comorbidity Symptoms by Inhibiting P2X7 Receptor

Frontiers in Psychiatry

2

周围神经

siRNA

Suppressing BRD4 exhibits protective effects against vincristineinduced peripheral neuropathy by alleviating inflammation and oxidative stress

Biochemical and Biophysical Research Communications

脊髓

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1

自身免疫性脑脊髓炎

miRNA

miR‑20a suppresses Treg differentiation by targeting Map3k9 in experimental autoimmune encephalomyelitis

Journal of Translational Medicine

2

创伤性

脊髓损伤

siRNA

MANF attenuates neuronal apoptosis and promotes behavioral recovery via Akt/MDM-2/p53 pathway after traumatic spinal cord injury in rats

BioFactors

眼睛

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1

角膜

siRNA

CD25 siRNA induces Treg/Th1 cytokine expression in rat corneal transplantation models

Experimental Eye Research

2

视网膜

miRNA mimic

Inhibitory role of miR-203 in the angiogenesis of mice with pathological retinal neovascularization disease through downregulation of SNAI2

Cellular Signalling

鼻

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1

鼻炎

miRNA mimic

MicroRNA-182-5p relieves murine allergic rhinitis via TLR4/NF-κB pathway

Open Medicine

口腔

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1

口腔鳞状

细胞癌

siRNA

OSCC cell‑secreted exosomal CMTM6 induced M2‑like macrophages polarization via ERK1/2 signaling pathway

Cancer Immunology, Immunotherapy

心脏

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1

心力衰竭

miRNA

Upregulation of miR-93 and inhibition of LIMK1 improve ventricular remodeling and alleviate cardiac dysfunction in rats with chronic heart failure by inhibiting RhoA/ROCK signaling pathway activation

AGING

2

心肌缺血

miRNA

MiR-23a Is Involved in Myocardial Ischemia/ Reperfusion Injury by Directly Targeting CX43 and Regulating Mitophagy

Inflammation

3

心肌损伤

siRNA

Role of high‐mobility group B1 in myocardial injury induced by coronary microembolization in rats

J Cell Biochem

4

病毒性心肌炎

shRNA

Short hairpin RNA targeting 2B gene of coxsackievirus B3 exhibits potential antiviral effects both in vitro and in vivo

BMC Infectious Diseases

支气管

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1

支气管

（哮喘）

miRNA

Divergent Roles of miR-3162-3p in Pulmonary Inflammation in Normal and Asthmatic Mice as well as Antagonism of miR-3162-3p in Asthma Treatment

Int Arch Allergy Immunol

2

支气管

（哮喘）

miRNA

Interference of miR-943-3p with secreted frizzled-related proteins4 (SFRP4) in an asthma mouse model

Cell and Tissue Research

肺部

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1

肺纤维化

pAAV-FTS1-GFP-miRNA

Transforming growth factor (TGF)-β1-induced

miR-133a inhibits myofibroblast differentiation and pulmonary fibrosis

Cell Death and Disease

2

肺泡出血

miRNA antagomir

In Vivo Therapeutic Success of MicroRNA-155 Antagomir in a Mouse Model of Lupus Alveolar Hemorrhage

ARTHRITIS & RHEUMATOLOGY

3

肺癌

miRNA

ENTPD5 Induces Apoptosis in Lung Cancer Cells via Regulating Caspase 3 Expression

PLOS ONE

4

肺损伤

siRNA

LPS-induced vein endothelial cell injury and acute lung injury have Btk and

Orai 1 to regulate SOC-mediated calcium influx

International Immunopharmacology

5

急性肺损伤

siRNA

CRBN knockdown mitigates lipopolysaccharide-induced acute lung injury by suppression of oxidative stress and endoplasmic reticulum (ER) stress associated NF-κB signaling

Biomedicine & Pharmacotherapy

6

肺动脉高压

shRNA

LncRNA Tug1 involves in the pulmonary vascular remodeling

in mice with hypoxic pulmonary hypertension via the microRNA-374c-mediated Foxc1

Life Sciences

胃

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1

胃癌

siRNA

CCDC65 as a new potential tumor suppressor induced by metformin inhibits activation of AKT1 via ubiquitination of ENO1 in gastric cancer

Theranostics

2

胃酸分泌

siRNA

Source of dopamine in gastric juice and luminal dopamine induced duodenal bicarbonate secretion via apical dopamine D2 receptors

The British Pharmacological Society

胰腺

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1

胰腺

（糖尿病）

circRNA

Circular RNA circPPM1F modulates M1 macrophage activation and pancreatic islet inflammation in type 1diabetes mellitus

Theranostics

肝脏

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1

肝脏炎症

miRNA agomir

Fine-tuning the expression of microRNA-155 controls acetaminophen-induced liver inflammation

International Immunopharmacology

2

肝损伤

siRNA

Astaxanthin attenuates hepatic damage and mitochondrial dysfunction in non-alcoholic fatty liver disease by upregulating the FGF21/PGC-1α pathway

The British Pharmacological Society

3

乙型肝炎

siRNA

Hepatitis B Virus Can Be Inhibited by DNA Methyltransferase 3a via Specific Zinc-Finger-Induced Methylation of the X Promoter

BIOCHEMISTRY

4

肝 (糖异生)

siRNA

Inactivation of NF-κB2 (p52) restrains hepatic glucagon response via preserving PDE4B induction

Nature Communications

5

肝癌

siRNA

MicroRNA-125b Attenuates Epithelial-Mesenchymal Transitions and Targets Stem-Like Liver Cancer Cells Through Small Mothers Against Decapentaplegic 2 and 4

HEPATOLOGY

6

急性肝衰竭

RNA mimics

Distinct effects of different doses of kaempferol on D‑GalN/LPS‑induced ALF depend on the autophagy pathway

Molecular Medicine REPORTS

7

非酒精性

脂肪肝

siRNA

Loss of RIP3 initiates annihilation of high-fat diet initialized nonalcoholic hepatosteatosis: A mechanism involving Toll-like receptor 4 and oxidative stress

Free Radical Biology and Medicine

肠

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1

结直肠

miRNA mimic

Fusobacterium nucleatum promotes chemoresistance to 5-fluorouracil by upregulation of BIRC3 expression in colorectal cancer

Cancer Letters

2

结直肠

siRNA

Fusobacterium nucleatum promotes chemoresistance to 5-fluorouracil by upregulation of BIRC3 expression in colorectal cancer

Journal of Experimental & Clinical Cancer Research

3

结肠

siRNA

Effect of vasopressin on Na⁺–K⁺–2Cl^– cotransporter(NKCC)and the signaling mechanisms on the murine late distal colon

European Journal of Pharmacology

4

肠道

siRNA

Advanced oxidation protein products induce G1 phase arrest in intestinal epithelial cells via a RAGE/CD36-JNK-p27kip1 mediated pathway

Redox Biology

骨

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1

软骨肉瘤

siRNA

BMPR2-pSMAD1/5 signaling pathway regulates RUNX2 expression and impacts the progression of dedifferentiated chondrosarcoma

Am J Cancer Res

2

骨形成

miRNA

miR-129-5p Inhibits Bone Formation Through TCF4

Frontiers in Cell and Developmental Biology

3

骨质疏松

shRNA

Extracellular regulated kinase 5 mediates osteoporosis through modulating viability and apoptosis of osteoblasts in ovariectomized rats

Bioscience Reports

4

骨坏死

siRNA

TET3 mediates alterations in the epigenetic marker 5hmC and Akt pathwayin steroid-associated osteonecrosis†

Journal of Bone and Mineral Research

5

骨关节炎

miRNA mimic

Upregulation of miR-98 Inhibits Apoptosis in Cartilage Cells in Osteoarthritis

GENETIC TESTING AND MOLECULAR BIOMARKERS

肌肉

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1

肌肉增殖

circRNA

CircRILPL1 promotes muscle proliferation and differentiation via binding miR-145 to activate IGF1R/PI3K/AKT pathway

Cell Death & Disease

2

骨骼肌萎缩

miRNA

MiR-206 Attenuates Denervation-Induced Skeletal Muscle Atrophy in Rats Through Regulation of Satellite Cell Differentiation via TGF-b1, Smad3, and HDAC4 Signaling

Med Sci Monit

3

肌肉生成

siRNA

HMGB2 Regulates Satellite Cell-Mediated Skeletal Muscle Regeneration via IGF2BP2

Journal of Cell Science

肾脏

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1

肾纤维化

miRNA

Regulation of connective tissue growth factor expression by miR-133b for the treatment of renal interstitial fibrosis in aged mice with unilateral ureteral obstruction

Stem Cell Research & Therapy

2

肾细胞癌

siRNA

Long non-coding RNA PCAT1 drives clear cell renal cell carcinoma by upregulating YAP via sponging miR-656 and miR-539

Cell Cycle

3

肾炎

miRNA agomir

MiR-130b ameliorates murine lupus nephritis through targeting type I interferon pathway on resident renal cells

Arthritis & Rheumatology

4

肾损伤

miRNA

miR-211 alleviates ischaemia/reperfusion-induced kidney injury by targeting TGFβR2/TGF-β/SMAD3 pathway

Bioengineered

膀胱

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1

膀胱癌

siRNA

Autophagy promotes oncolysis of an adenovirus expressing apoptin in human bladder cancer models

Investigational New Drugs

乳腺

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1

乳腺癌

miRNA inhibitor

ZLM‑7 inhibits the occurrence and angiogenesis of breast cancer through miR‑212‑3p/Sp1/VEGFA signal

Molecular Medicine

2

乳腺癌

shRNA

Short hairpin RNA targeting 2B gene of coxsackievirus B3 exhibits potential antiviral effects both in vitro and in vivo

BMC Infectious Diseases

生殖系统

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1

卵巢癌

shRNA

LncRNA MAFG-AS1 promotes the malignant phenotype of ovarian cancer by upregulating NFKB1-dependent IGF1

Cancer Gene Therapy

2

睾丸生殖

细胞肿瘤

miRNA antagomir

A miR-125b/CSF1-CX3CL1/tumorassociated macrophage recruitment axis controls testicular germ cell tumor growth

Cell Death and Disease

腹膜

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1

腹膜纤维化

miRNA inhibitor

Long noncoding RNA AK089579 inhibits epithelial-to-mesenchymal transition of peritoneal mesothelial cells by competitively binding to microRNA-296-3p via DOK2 in peritoneal fibrosis

The FASEB Journal

免疫系统

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1

红斑狼疮

miRNA

LncRNA MIAT enhances systemic lupus erythematosus by upregulating CFHR5 expression via miR-222 degradation

Experimental immunology

2

肥大细胞

荨麻疹

siRNA

SELE Downregulation Suppresses Mast Cell Accumulation to Protect against Inflammatory Response in Chronic Idiopathic Urticaria

Int Arch Allergy Immunol

3

自身免疫性

脑脊髓炎

miRNA

miR‑20a suppresses Treg differentiation by targeting Map3k9 in experimental autoimmune encephalomyelitis

Journal of Translational Medicine

皮肤

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1

疤痕

miRNA

miR-29b promotes skin wound healing and reduces excessive scar formation by inhibition of TGF-β1/Smad/CTGF signaling pathway

Canadian Journal of Physiology and Pharmacology

动物

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1

七鳃鳗

miRNA mimics, inhibitor

MicroRNA expression profile in Lampetra morii upon Vibrio anguillarum infection and miR-4561 characterization targeting lip

COMMUNICATIONS BIOLOGY

2

海参

dsRNA

Wnt Signaling Pathway Linked to Intestinal Regeneration via Evolutionary Patterns and Gene Expression in the Sea Cucumber Apostichopus japonicus

Frontiers in Genetics

3

鸡胚

siRNA

lnc-3215 Suppression Leads to Calcium Overload in Selenium Deficiency-Induced Chicken Heart Lesion via the lnc-3215-miR-1594-TNN2 Pathway

Molecular Therapy: Nucleic Acids

4

飞蝗

miRNA

The microRNAs let-7 and miR-278 regulate insect metamorphosis and oogenesis by targeting the juvenile hormone early-response gene Krüppel-homolog 1

The Company of Biologists Ltd

5

幼蟹

siRNA

Molecular characteristics and abundance of insulin-like androgenic gland

hormone and effects of RNA interference in Eriocheir sinensis

Animal Reproduction Science

6

半滑舌鳎鱼

siRNA

Global profiling of megalocytivirus-induced proteins in tongue sole (Cynoglossussemilaevis) spleen identifies cellular processes essential to viral infection

Developmental and Comparative Immunology

7

猪

siRNA

Coronary Microembolization Induces Cardiomyocyte Apoptosis in Swine by Activating the LOX-1-Dependent Mitochondrial Pathway and Caspase-8-Dependent Pathway

Journal of Cardiovascular

Pharmacology and Therapeutics