发表在《Stem Cell Research & Therapy 》期刊的“Regulation of connective tissue growth factor expression by miR-133b for thetreatment of renal interstitial fibrosis in aged mice with unilateral ureteral obstruction“文章表明CTGF是 miR-133b 的靶基因,参与改善肾纤维化。研究人员通过miR-133b模拟物的体内转染(EntransterTM-in vivo, Engreen)实验 ,确定了miR-133b对单侧输尿管梗阻的老年小鼠肾间质纤维化具有缓解作用,能改善老年人肾间质纤维化,有助于延缓肾脏衰老。这些结果为基于miR-133b的药物开发提供了基础研究证据。